Amikishieva A V, Kozlova O N, Serov L I, Naumenko E V
Fiziol Zh Im I M Sechenova. 1996 Oct-Nov;82(10-11):84-90.
A unilateral hemicastration decreased the serotonin and 5-hydroxyindolacetic acid levels in the Wistar rat mediobasal hypothalamus, but not in the midbrain. These neurotransmitters were shown to interact in the process of androgen restoration after the hemicastration. The maximal contribution of GABAergic mechanisms in the testosterone feedback regulation involves the GABA effect via the central GABA-A receptors of the mediobasal hypothalamus' serotoninergic neurons, thus activating the hormone level restoration. The GABA seems to induce a serotonin-independent inhibition of the testosterone level stabilising after hemicastration.
单侧睾丸切除降低了Wistar大鼠中基底部下丘脑而非中脑中血清素和5-羟吲哚乙酸的水平。这些神经递质在单侧睾丸切除后的雄激素恢复过程中相互作用。GABA能机制在睾酮反馈调节中的最大作用涉及通过中基底部下丘脑血清素能神经元的中枢GABA-A受体产生的GABA效应，从而激活激素水平的恢复。GABA似乎在单侧睾丸切除后诱导了一种不依赖血清素的对睾酮水平稳定的抑制作用。
