Kendall J D, Chrymko M M, Cooper B E
Pharmacy Service, Department of Veterans Affairs Medical Center, Erie, PA 16504.
Pharmacotherapy. 1992;12(5):416-8.
Theophylline and mexiletine can be prescribed in patients with chronic obstructive pulmonary disease with coexistent arrhythmias. The drugs have common metabolic pathways that may result in an interaction. A patient who was taking theophylline became toxic after the initiation of mexiletine. Discontinuation of mexiletine led to an improvement in theophylline clearance.
对于患有慢性阻塞性肺疾病且并存心律失常的患者，可以开具氨茶碱和美西律。这两种药物具有共同的代谢途径，可能会导致相互作用。一名正在服用氨茶碱的患者在开始服用美西律后出现中毒症状。停用美西律后，氨茶碱的清除率有所改善。
