Nakamura K, Takashima S, Nakatsuka H, Onoyama Y
Department of Radiology, Osaka City University School of Medicine, Japan.
Radiology. 1992 Dec;185(3):885-9. doi: 10.1148/radiology.185.3.1438780.
Twenty-one patients with prostate cancer underwent intermittent arterial infusion chemotherapy with an implanted reservoir and alteration of the intrapelvic blood flow. One internal iliac artery was embolized with steel coils so that the drugs would perfuse throughout the tumor through a single tube. Angiography performed after embolization showed distinct tumor vessels. Intensive radioisotope accumulation was demonstrated in the prostate gland at scintigraphy performed with technetium-99m macroaggregated albumin. Ten milligrams each of cisplatin and doxorubicin were injected once a week by means of puncture of the implanted reservoir. All patients had more than a 50% reduction in tumor size. The response rate to this treatment was good; six patients experienced complete response, and 13 had partial response. Two patients had progressive disease. With this technique, small doses of the anticancer agents reached the tumor in high concentrations. Results were good, with few side effects.
21例前列腺癌患者接受了带植入式储液器的间歇性动脉灌注化疗及盆腔内血流改道。一条髂内动脉用钢圈栓塞，以便药物通过单根导管灌注整个肿瘤。栓塞后行血管造影显示肿瘤血管清晰。用99m锝标记的大聚合白蛋白进行闪烁扫描时，前列腺内显示出强烈的放射性同位素聚集。通过穿刺植入式储液器，每周注射顺铂和阿霉素各10毫克。所有患者肿瘤大小均缩小50%以上。该治疗的有效率良好；6例患者完全缓解，13例部分缓解。2例患者疾病进展。采用该技术，小剂量抗癌药物能高浓度到达肿瘤部位。结果良好，副作用少。
