血液透析对慢性肾衰竭患者脂质过氧化及抗氧化系统的影响。
Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure.
作者信息
Mohora M, Mircescu G, Cîrjan C, Mihăilescu I, Gîrneaţă L, Ursea N, Dinu V
机构信息
Carol Davila University of Medicine and Pharmacy, Department of Biochemistry, Bucharest, Romania.
出版信息
Rom J Intern Med. 1995 Jul-Dec;33(3-4):237-42.
Plasma and blood lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD), and serum antioxidant activity (AOA) in uremic patients were examined before and 15 and 30 minutes after the start of dialysis. Hemodialysis was found to produce increased lipid peroxidation in plasma and blood and a simultaneous decrease of SOD activity. The extracellular antioxidant systems were evaluated by the assay of ceruloplasmin level, which did not modify significantly during the dialysis. Our data indicate that the time since the start of dialysis is an important, but not unique factor, influencing possible oxidative damage during hemodialysis.
对尿毒症患者在透析开始前、开始后15分钟和30分钟检测血浆和血脂过氧化、红细胞超氧化物歧化酶（SOD）活性以及血清抗氧化活性（AOA）。发现血液透析会使血浆和血液中的脂质过氧化增加，同时SOD活性降低。通过检测铜蓝蛋白水平评估细胞外抗氧化系统，其在透析过程中无显著变化。我们的数据表明，透析开始后的时间是影响血液透析期间可能发生的氧化损伤的一个重要但并非唯一的因素。
Zotero 插件