Oduola A M, Sowunmi A, Milhous W K, Kyle D E, Martin R K, Walker O, Salako L A
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Nigeria.
Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):123-6. doi: 10.1016/0035-9203(92)90533-i.
The rapid dissemination of chloroquine-resistant Plasmodium falciparum in West Africa has been well documented and represents a significant health threat to autochthonous populations. The methodical development of alternative chemotherapeutic agents demands that dispensing new antimalarial drugs (mefloquine, halofantrine, and artemisinine [qinghaosu]) be closely monitored in order to protect their clinical utility. Indeed, mefloquine-resistant strains of P. falciparum have been reported. We present data from experiments in vitro on the innate resistance of P. falciparum isolates to mefloquine as well as a disturbing observation of transient resistance to artemisinine. The implications for the extended efficacy of these new antimalarial drugs are addressed.
氯喹抗性恶性疟原虫在西非的迅速传播已有充分记录，对当地居民构成了重大健康威胁。系统地研发替代化疗药物要求密切监测新抗疟药物（甲氟喹、卤泛群和青蒿素）的使用，以保护其临床效用。事实上，已有报告称出现了对甲氟喹耐药的恶性疟原虫菌株。我们展示了体外实验中恶性疟原虫分离株对甲氟喹的天然抗性数据，以及对青蒿素短暂抗性的令人不安的观察结果。文中探讨了这些新抗疟药物延长疗效的意义。
