Brown A E, Herrington D A, Webster H K, Clyde D F, Sztein M B, Davis J R, Beier M S, Edelman R
Department of Immunology, Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):134-6. doi: 10.1016/0035-9203(92)90539-o.
To investigate the kinetics of monocyte/macrophage activation in falciparum malaria we determined urinary neopterin values serially in experimentally infected volunteers. Three subjects who had been immunized with irradiated sporozoites via mosquito bites served as controls. These individuals remained aparasitaemic, afebrile and without a rise in neopterin after challenge by infective mosquitoes. Four non-immune subjects developed Plasmodium falciparum parasitaemia, fever (3 of 4) and sharp rises in neopterin. Parasite densities reached 10-100 parasitized erythrocytes per microliter before elevations in temperature or neopterin levels were detected. Onset of fever preceded the rise in neopterin excretion by one day. Prompt chemotherapy was associated with the clearance of parasites from the blood and the return of temperature and neopterin levels to normal.
为了研究恶性疟原虫感染中单核细胞/巨噬细胞激活的动力学，我们对实验感染的志愿者连续测定尿新蝶呤值。三名通过蚊虫叮咬接种过辐照子孢子的受试者作为对照。这些个体在受到感染性蚊虫攻击后仍未出现寄生虫血症、发热，新蝶呤也未升高。四名非免疫受试者出现了恶性疟原虫血症、发热（4例中的3例）和新蝶呤急剧升高。在检测到体温或新蝶呤水平升高之前，寄生虫密度达到每微升10 - 100个被寄生的红细胞。发热 onset 比新蝶呤排泄增加提前一天。及时化疗与血液中寄生虫的清除以及体温和新蝶呤水平恢复正常有关。
