Meskin S, Jacob M S, Macaden R, Keystone J S, Kozarsky P E, Ramachadran A N, Metchock B
Emory University School of Medicine, Atlanta, Georgia.
Trans R Soc Trop Med Hyg. 1992 Jul-Aug;86(4):446-7. doi: 10.1016/0035-9203(92)90264-d.
This study assessed the performance of short-course ciprofloxacin for the treatment of 34 adult patients with culture-positive typhoid fever. Patients received ciprofloxacin, 750 mg orally twice daily for 7 d. Measurement of response was based upon time from initial treatment to fever lysis, to afebrile state, and to symptom resolution. Ciprofloxacin-treated patients defervesced in a mean of 3.21 d (+/- 0.56), with stabilization of temperature in 4.0 +/- 0.73 d. After 90 d follow-up, no relapse or carrier was identified. Side effects during therapy were minimal.
本研究评估了短程环丙沙星治疗34例血培养确诊的成人伤寒热患者的疗效。患者口服环丙沙星，750毫克，每日两次，共7天。疗效评估基于从初始治疗到热退、体温恢复正常及症状缓解的时间。接受环丙沙星治疗的患者平均3.21天（±0.56）退热，4.0±0.73天体温稳定。90天随访后，未发现复发或带菌者。治疗期间副作用极小。
