Dutta P, Rasaily R, Saha M R, Mitra U, Bhattacharya S K, Bhattacharya M K, Lahiri M
National Institute of Cholera and Enteric Diseases, Calcutta, India.
Antimicrob Agents Chemother. 1993 May;37(5):1197-9. doi: 10.1128/AAC.37.5.1197.
Eighteen children with bacteriologically confirmed severe typhoid fever were initially treated intravenously with ciprofloxacin (10 mg/kg of body weight per day). Clinical cure with eradication of multiresistant Salmonella typhi infection was observed in 17 patients (94.4%; 95% confidence interval [CI], 84 to 100%). Children regained normal consciousness within an average of 2 days (95% CI, 1.8 to 2.2 days). The temperatures of the children returned to normal within 3.3 days (95% CI, 3.1 to 3.5 days). Complications were not observed during the hospital stay or a 3-month follow-up period. Relapse and carrier state were also not encountered during the follow-up period.
18名经细菌学确诊的重症伤寒患儿最初接受环丙沙星静脉治疗（每日10毫克/千克体重）。17例患者（94.4%；95%置信区间[CI]，84%至100%）实现临床治愈且多重耐药伤寒杆菌感染被根除。患儿平均在2天内（95%CI，1.8至2.2天）恢复意识。患儿体温在3.3天内（95%CI，3.1至3.5天）恢复正常。住院期间及3个月随访期内未观察到并发症。随访期内也未出现复发及带菌状态。
