Kravtsov V Iu, Gorokhov S V, Kaminskaia E V, Il'inskikh N N, Vakhtin Iu B
Tsitologiia. 1992;34(3):28-30.
Cell suspensions of rat transplantable rhabdomyosarcoma RA-2 were injected to white rats. The experimentally induced lung metastases (ELM) were estimated according to the frequency of micronucleated cells (MNC) that appeared 9-20 days after injection (a. i.). The frequency of MNC in ELM decreased from 2.7% (9 days a. i.) to 0.7% (20 days a. i.). The ELM which were of the same size but were examined at different time after injection had equal frequencies of MNC. At each investigated time after injection the least frequencies of MNC were observed in the ELV of the biggest size. The data provided allow to infer that the growth time and site of ELM may influence the spontaneous karyotype instability rates.
将大鼠可移植性横纹肌肉瘤RA - 2的细胞悬液注射到白鼠体内。根据注射后9 - 20天出现的微核细胞（MNC）频率估算实验诱导的肺转移（ELM）情况。ELM中MNC的频率从注射后9天的2.7%降至注射后20天的0.7%。大小相同但在注射后不同时间检查的ELM具有相同的MNC频率。在注射后的每个研究时间点，最大尺寸的ELV中观察到的MNC频率最低。所提供的数据表明，ELM的生长时间和部位可能会影响自发核型不稳定性率。
