Caradonna P, Gentiloni N, Servidei S, Perrone G A, Greco A V, Russo M A
Institute of Clinical Medicine, Faculty of Medicine, Catholic University, Rome, Italy.
Ultrastruct Pathol. 1992 Sep-Oct;16(5):529-35. doi: 10.3109/01913129209061544.
A patient with acute rhabdomyolysis and absence of myoadenylate deaminase (MADA) associated with chronic licorice intoxication is presented. Clinical and laboratory examination of the patient and morphologic study over skeletal muscle were performed. The major effect of licorice intoxication is hypokalemia, which may explain most of the observed clinical symptoms and morphological changes. The absence of MADA may be a consequence of the direct toxic effect of licorice glycosides. To our knowledge, this is the first report in which a lack of MADA and chronic licorice intoxication has been shown to be associated with clinical, histochemical, biochemical, and morphological changes, which were completely reversed with potassium supplementation and licorice withdrawal.
本文报告了一名患有急性横纹肌溶解症且缺乏肌腺苷酸脱氨酶（MADA）的患者，该患者与慢性甘草中毒有关。对患者进行了临床和实验室检查，并对骨骼肌进行了形态学研究。甘草中毒的主要影响是低钾血症，这可能解释了观察到的大多数临床症状和形态学变化。MADA的缺乏可能是甘草苷直接毒性作用的结果。据我们所知，这是第一份报告，显示MADA缺乏与慢性甘草中毒与临床、组织化学、生化和形态学变化相关，通过补充钾和停用甘草，这些变化完全逆转。
