Kodentsova V M, Vrzhesinskaia O A, Kharitonchik L A, Spirichev V B
Vopr Med Khim. 1994 Mar-Apr;40(2):41-5.
No differences were found in the rate of metabolism of vitamins B1, B2, B6 and niacin either in healthy persons or in patients with duodenal ulcer, hypertension of the 2nd degree and with ischemic heart disease as shown by excretion of riboflavin, 4-pyridoxylic acid, 1-methyl nicotinamide and thiamin with urine which correlated with concentration of these vitamins and their coenzyme forms in blood plasma and erythrocytes. Dependence of these vitamins excretion with urine on their concentration in blood and the vitamins content in food appear to demonstrate similar consumption of vitamins B in the persons studied; at the same time, evaluation of the vitamins consumption in the patients with these forms of pathology should be performed using the criteria suitable for healthy persons. Dissimilar rates of metabolism of these vitamins described in literature might be related to differences in nutrition as well as to the use of nonspecific techniques for estimation of the vitamins. Besides, initial consumption of vitamin B2 was not sometimes considered, but deficiency in riboflavin caused considerable impairments of vitamin B6 and niacin metabolism.
在健康人以及患有十二指肠溃疡、二级高血压和缺血性心脏病的患者中，未发现维生素B1、B2、B6和烟酸的代谢率存在差异，这一点通过尿中核黄素、4-吡啶氧酸、1-甲基烟酰胺和硫胺素的排泄得以体现，这些物质的排泄与血浆和红细胞中这些维生素及其辅酶形式的浓度相关。这些维生素随尿液的排泄量与其在血液中的浓度以及食物中维生素含量的依赖关系，似乎表明所研究人群对维生素B的消耗量相似；与此同时，对于患有这些病理形式的患者，应使用适合健康人的标准来评估维生素的消耗量。文献中描述的这些维生素不同的代谢率可能与营养差异以及用于评估维生素的非特异性技术有关。此外，有时没有考虑维生素B2的初始消耗量，但核黄素缺乏会导致维生素B6和烟酸代谢的显著受损。
