Matas A J, Payne W D, Grotting J C, Sutherland D E, Steffes M W, Hertel B F, Najarian J S
Transplantation. 1977 Nov;24(5):333-7. doi: 10.1097/00007890-197711000-00004.
It is not known whether the advantage of the portal vein as a transplant site for islet transplantation is caused by the immediate availability of a blood supply or by the localization of the islets in the portal circulation. We transplanted minimal quantities of islet tissue from neonatal rat donors to isogeneic adult rats with streptozotocin-induced diabetes. Transplants were performed to three sites, i.p., portal vein, and systemic vein (i.v.). When four neonatal donors were used for each recipient there were no i.p. cures but 90% i.v. and 100% portal vein cures, which suggests that access to a blood supply is important. As the amount of tissue transplanted was decreased, there were significantly more cures with the portal vein route, which suggests that localization of the islets in the portal circulation is also important to graft survival.
尚不清楚门静脉作为胰岛移植部位的优势是由血液供应的即时可得性还是胰岛在门静脉循环中的定位所导致。我们将极少量来自新生大鼠供体的胰岛组织移植到链脲佐菌素诱导糖尿病的同基因成年大鼠体内。移植分别在三个部位进行，即腹腔内、门静脉和体静脉（静脉内）。当每个受体使用四个新生供体时，腹腔内移植没有治愈成功的情况，但静脉内移植的治愈率为90%，门静脉移植的治愈率为100%，这表明获得血液供应很重要。随着移植组织量的减少，门静脉途径的治愈成功率显著更高，这表明胰岛在门静脉循环中的定位对移植物存活也很重要。
