Sompolinsky D, Katzenstein T, Lundberg L
Institute of Medical Microbiology, University of Copenhagen, Denmark.
Allergy. 1992 Aug;47(4 Pt 1):303-8. doi: 10.1111/j.1398-9995.1992.tb02058.x.
Circulatory basophilia could be induced in inbred guinea pigs systematically immunized with ovalbumin and consequently provoked repeatedly with dissolved ovalbumin applied onto the mucosa of the nares or the outer eye. The degree of the increase in circulatory basophil granulocytes depended on the adjuvant used and was significantly more pronounced after immunization with Freund's complete adjuvant than with alhydrogel (Al(OH)3). The degree of basophilia was also dependent on the animal strain, but different in two strains selected for high-asthma trait.
在经卵清蛋白系统免疫的近交系豚鼠中，可诱导循环嗜碱性粒细胞增多，随后通过将溶解的卵清蛋白应用于鼻黏膜或外眼部反复激发。循环嗜碱性粒细胞增多的程度取决于所用佐剂，用弗氏完全佐剂免疫后比用氢氧化铝佐剂更明显。嗜碱性粒细胞增多的程度也取决于动物品系，但在两个选择用于高哮喘特征的品系中有所不同。
