佐剂对体液免疫和细胞介导免疫的比较选择性。II. 弗氏不完全佐剂和完全佐剂、氢氧化铝凝胶、短小棒状杆菌、百日咳博德特氏菌、胞壁酰二肽和皂苷对小鼠和豚鼠迟发型超敏反应以及小鼠对肿瘤抗原的细胞介导免疫的影响
The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.
作者信息
Bomford R
出版信息
Clin Exp Immunol. 1980 Feb;39(2):435-41.
Abstract
Corynebacterium parvum was the only adjuvant of those tested which consistently potentiated delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) in the mouse, although this required the antigen-adjuvant mixture to be injected subcutaneously in the footpad rather than the flank. For induction of DTH to ovalbumin (OVA) in the guinea pig, C. parvum and MDP could be substituted for the mycobacteria in FCA. C. parvum was effective in aqueous solution provided that the OVA was absorbed onto alhydrogel. Saponin also potentiated DTH when injected with OVA in aqueous solution. C. parvum was the sole adjuvant of those tested to promote protective cell-mediated immunity (CMI) to M4 fibrosarcoma cells. It is concluded that C. parvum is a promising candidate adjuvant for promoting CMI induction without recourse to a water-in-oil emulsion.
摘要
细小棒状杆菌是所测试的佐剂中唯一能持续增强小鼠对绵羊红细胞（SRBC）迟发型超敏反应（DTH）的佐剂，不过这需要将抗原 - 佐剂混合物注射到脚垫皮下而非胁腹。对于在豚鼠中诱导对卵清蛋白（OVA）的DTH，细小棒状杆菌和MDP可以替代弗氏完全佐剂（FCA）中的分枝杆菌。如果OVA吸附到氢氧化铝凝胶上，细小棒状杆菌在水溶液中也有效。皂苷与水溶液中的OVA一起注射时也能增强DTH。细小棒状杆菌是所测试的佐剂中唯一能促进对M4纤维肉瘤细胞的保护性细胞介导免疫（CMI）的佐剂。得出的结论是，细小棒状杆菌是一种有前景的候选佐剂，可用于促进CMI诱导，而无需借助油包水乳液。
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