低剂量甲氧苄啶-磺胺甲恶唑单独及与齐多夫定联合用于预防和治疗小鼠卡氏肺孢子虫肺炎
Low-dose trimethoprim-sulfamethoxazole alone and in association with zidovudine for prevention and treatment of murine Pneumocystis carinii pneumonia.
作者信息
Brun-Pascaud M, Girard P M, Pocidalo J J
机构信息
Institut National de la Santé et de la Recherche Médicale, U. 13, Hôpital Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1992 Oct;36(10):2328-30. doi: 10.1128/AAC.36.10.2328.
Abstract
Low-dose trimethoprim-sulfamethoxazole (TMP-SMX) alone was found to be as effective as low-dose TMP-SMX plus zidovudine and standard-dose TMP-SMX alone in preventing and treating Pneumocystis carinii pneumonia (PCP) in an immunosuppressed-rat model. Zidovudine alone had no preventive or curative effect on PCP. We conclude that the initially reported reduced incidence of PCP in human immunodeficiency virus-infected patients treated with zidovudine alone is not due to anti-P. carinii activity of zidovudine. Furthermore, the clinical efficacy of low-dose TMP-SMX for the prevention and treatment of PCP should be further investigated.
摘要
在免疫抑制大鼠模型中，单独使用低剂量甲氧苄啶-磺胺甲恶唑（TMP-SMX）预防和治疗卡氏肺孢子虫肺炎（PCP），被发现与低剂量TMP-SMX加齐多夫定以及单独使用标准剂量TMP-SMX一样有效。单独使用齐多夫定对PCP没有预防或治疗作用。我们得出结论，最初报道的单独使用齐多夫定治疗的人类免疫缺陷病毒感染患者中PCP发病率降低，并非由于齐多夫定的抗卡氏肺孢子虫活性。此外，低剂量TMP-SMX预防和治疗PCP的临床疗效应进一步研究。
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