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酵母中翻译的分子生物学

Molecular biology of translation in yeast.

作者信息

Linder P

机构信息

Department of Microbiology, Biozentrum, Basel, Switzerland.

出版信息

Antonie Van Leeuwenhoek. 1992 Aug;62(1-2):47-62. doi: 10.1007/BF00584462.

DOI:10.1007/BF00584462
PMID:1444336
Abstract

The combination of genetic, molecular and biochemical approaches have made the yeast Saccharomyces cerevisiae a convenient organism to study translation. The sequence similarity of translation factors from yeast and other organisms suggests a high degree of conservation in the translational machineries. This view is also strengthened by a functional analogy of some proteins implicated in translation. Beautiful genetic experiments have confirmed existing models and added new insights in the mechanism of translation. This review summarizes recent experiments using yeast as a model system for the analysis of this complex process.

摘要

遗传、分子和生化方法的结合，使酿酒酵母成为研究翻译的便利生物体。酵母与其他生物体翻译因子的序列相似性表明，翻译机制具有高度保守性。一些与翻译相关的蛋白质的功能相似性也强化了这一观点。出色的遗传学实验证实了现有模型，并为翻译机制增添了新的见解。本综述总结了最近以酵母为模型系统分析这一复杂过程的实验。

相似文献

1
Molecular biology of translation in yeast.酵母中翻译的分子生物学
Antonie Van Leeuwenhoek. 1992 Aug;62(1-2):47-62. doi: 10.1007/BF00584462.
2
Baker's yeast, the new work horse in protein synthesis studies: analyzing eukaryotic translation initiation.面包酵母，蛋白质合成研究中的新主力军：分析真核生物翻译起始
Bioessays. 1990 Nov;12(11):519-26. doi: 10.1002/bies.950121103.
3
Potential extra-ribosomal functions of ribosomal proteins in Saccharomyces cerevisiae.核糖体蛋白在酿酒酵母中的核糖体外潜在功能。
Microbiol Res. 2015 Aug;177:28-33. doi: 10.1016/j.micres.2015.05.004. Epub 2015 May 19.
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N(α)-Acetylation of yeast ribosomal proteins and its effect on protein synthesis.酵母核糖体蛋白的 N(α)-乙酰化及其对蛋白质合成的影响。
J Proteomics. 2011 Apr 1;74(4):431-41. doi: 10.1016/j.jprot.2010.12.007. Epub 2010 Dec 22.
5
Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation.酿酒酵母中的核糖体蛋白甲基转移酶：在核糖体生物合成和翻译中的作用。
Biochem Biophys Res Commun. 2016 Feb 12;470(3):552-557. doi: 10.1016/j.bbrc.2016.01.107. Epub 2016 Jan 20.
6
Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational activator PET122 by mutations in two new genes, MRP17 and PET127.通过两个新基因MRP17和PET127中的突变抑制酵母线粒体mRNA特异性翻译激活因子PET122的羧基末端截短。
Mol Gen Genet. 1992 Oct;235(1):64-73. doi: 10.1007/BF00286182.
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The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation.酵母SIS1蛋白是一种DnaJ同源物，是翻译起始所必需的。
Cell. 1993 Jun 18;73(6):1175-86. doi: 10.1016/0092-8674(93)90646-8.
8
Molecular genetics of the peptidyl transferase center and the unusual Var1 protein in yeast mitochondrial ribosomes.酵母线粒体核糖体中肽基转移酶中心和异常Var1蛋白的分子遗传学
Experientia. 1996 Dec 15;52(12):1148-57. doi: 10.1007/BF01952114.
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Translation elongation factor 1 functions in the yeast Saccharomyces cerevisiae.翻译延伸因子1在酿酒酵母中发挥作用。
Cold Spring Harb Symp Quant Biol. 2001;66:439-48. doi: 10.1101/sqb.2001.66.439.
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The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs.核糖体蛋白Asc1/RACK1是短mRNA高效翻译所必需的。
Elife. 2016 Apr 27;5:e11154. doi: 10.7554/eLife.11154.

引用本文的文献

1
Posttranscriptional control of gene expression in yeast.酵母中基因表达的转录后调控
Microbiol Mol Biol Rev. 1998 Dec;62(4):1492-553. doi: 10.1128/MMBR.62.4.1492-1553.1998.
2
The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability.酵母转录因子基因YAP1和YAP2在翻译和mRNA稳定性水平上受到差异调控。
Nucleic Acids Res. 1998 Mar 1;26(5):1150-9. doi: 10.1093/nar/26.5.1150.
3
TOR controls translation initiation and early G1 progression in yeast.

本文引用的文献

1
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Analysis of temperature-sensitive mutant ts 187 of Saccharomyces cerevisiae altered in a component required for the initiation of protein synthesis.对酿酒酵母温度敏感突变体ts 187的分析，该突变体在蛋白质合成起始所需的一个组分中发生了改变。
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TOR控制酵母中的翻译起始和G1期早期进程。
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Cloning and characterization of a TEF gene for elongation factor 1 alpha from the yeast Arxula adeninivorans.来自嗜腺阿舒囊酵母的延伸因子1α的TEF基因的克隆与特性分析
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5
Influence of the three nucleotides upstream of the initiation codon on expression of the Escherichia coli lacZ gene in Saccharomyces cerevisiae.起始密码子上游三个核苷酸对酿酒酵母中大肠杆菌lacZ基因表达的影响。
Nucleic Acids Res. 1993 Sep 11;21(18):4268-71. doi: 10.1093/nar/21.18.4268.
6
A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase.一种新的酵母翻译起始因子抑制了真核翻译起始因子4A（eIF-4A）RNA解旋酶中的一个突变。
EMBO J. 1993 Oct;12(10):4005-11. doi: 10.1002/j.1460-2075.1993.tb06078.x.
7
A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity.酿酒酵母中哺乳动物翻译起始因子4B的同源物有助于RNA解旋酶活性。
EMBO J. 1993 Oct;12(10):3997-4003. doi: 10.1002/j.1460-2075.1993.tb06077.x.
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Polypeptide chain termination in Saccharomyces cerevisiae.酿酒酵母中的多肽链终止
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Codon selection in yeast.
酵母中的密码子选择
J Biol Chem. 1982 Mar 25;257(6):3026-31.
4
Involvement of eukaryotic initiation factor 4A in the cap recognition process.真核生物起始因子4A在帽识别过程中的作用。
J Biol Chem. 1983 Sep 25;258(18):11398-403.
5
Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae.酿酒酵母翻译延伸因子EF-1α编码的两个基因的鉴定。
EMBO J. 1984 Dec 20;3(13):3311-5. doi: 10.1002/j.1460-2075.1984.tb02295.x.
6
Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae.酵母的多肽链延伸因子1α（EF-1α）：酿酒酵母EF-1α两个基因之一的核苷酸序列。
EMBO J. 1984 Aug;3(8):1825-30. doi: 10.1002/j.1460-2075.1984.tb02053.x.
7
Assembly of the mitochondrial membrane system. Nucleotide sequence of a yeast nuclear gene (CBP1) involved in 5' end processing of cytochrome b pre-mRNA.线粒体膜系统的组装。参与细胞色素b前体mRNA 5'端加工的酵母核基因（CBP1）的核苷酸序列。
J Biol Chem. 1984 Apr 25;259(8):4732-8.
8
In vivo transcription of a eukaryotic regulatory gene.真核生物调控基因的体内转录。
EMBO J. 1983;2(12):2179-84. doi: 10.1002/j.1460-2075.1983.tb01720.x.
9
Temperature-sensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis.表现出蛋白质合成快速抑制的酵母温度敏感突变体。
J Bacteriol. 1968 Nov;96(5):1664-71. doi: 10.1128/jb.96.5.1664-1671.1968.
10
A mutant of yeast apparently defective in the initiation of protein synthesis.一种明显在蛋白质合成起始阶段存在缺陷的酵母突变体。
Proc Natl Acad Sci U S A. 1969 Feb;62(2):468-74. doi: 10.1073/pnas.62.2.468.