Rösel H, Kunze G
Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.
Curr Genet. 1995 Sep;28(4):360-6. doi: 10.1007/BF00326434.
The translation elongation factor EF-1 alpha appears to play a major role in the control of cell proliferation and ageing in higher eukaryotes. Here we report the cloning of the TEF1 gene encoding the elongation factor 1 alpha of the dimorphic yeast Arxula adeninivorans Ls3. The gene is localized on chromosome 2 from Arxula adeninivorans, comprises 1380 bp and encodes a protein containing 459 amino acids. In contrast to other fungi, a second TEF gene encoding an identical, or nearly identical, polypeptide could not be identified. The transcriptional activity of the TEF1 gene did not change during mycelial growth, whereas a slight decrease could be detected during the yeast growth.
翻译延伸因子EF-1α似乎在高等真核生物的细胞增殖和衰老控制中起主要作用。在此，我们报告了编码双态酵母嗜腺嘌呤阿苏菌Ls3延伸因子1α的TEF1基因的克隆。该基因位于嗜腺嘌呤阿苏菌的2号染色体上，由1380个碱基对组成，编码一个含有459个氨基酸的蛋白质。与其他真菌不同，未发现编码相同或几乎相同多肽的第二个TEF基因。TEF1基因的转录活性在菌丝体生长过程中没有变化，而在酵母生长过程中可检测到轻微下降。
