接受地塞米松治疗支气管肺发育不良的胃肠外营养婴儿血浆氨基酸谱的变化
Changes in the plasma aminogram of parenterally fed infants treated with dexamethasone for bronchopulmonary dysplasia.
作者信息
Ng P C, Brownlee K G, Kelly E J, Henderson M J, Smith M, Dear P R
机构信息
Department of Paediatrics and Child Health, St James's University Hospital, Leeds.
出版信息
Arch Dis Child. 1992 Oct;67(10 Spec No):1193-5. doi: 10.1136/adc.67.10_spec_no.1193.
Abstract
A substantial increase in the plasma concentration of most amino acids was observed in 59 preterm infants with chronic lung disease soon after the initiation of dexamethasone therapy. The size of increase appeared to be dose related. This phenomenon is likely to be the result of steroid induced protein catabolism. Interestingly, neither phenylalanine nor tyrosine concentrations were significantly increased.
摘要
在59例患有慢性肺病的早产儿中，地塞米松治疗开始后不久，观察到大多数氨基酸的血浆浓度大幅升高。升高的幅度似乎与剂量有关。这种现象可能是类固醇诱导的蛋白质分解代谢的结果。有趣的是，苯丙氨酸和酪氨酸的浓度均未显著升高。
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