Ando K, Manabe T, Tobe T
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Nihon Geka Hokan. 1992 May 1;61(3):259-67.
In order to clarify the effect of prostaglandin E2 (PGE2) on cerulein-induced rat pancreatitis, we investigated the interaction of PGE2 with cerulein or secretin. Intravenous infusion of 10 micrograms/kg.h cerulein inhibited external secretion of the pancreas from one hour and caused macroscopic edema at 3 hours. Administration of PGE2 relieved the inhibitory effect of supramaximal dose of cerulein and decreased the pancreatic edema. The 100 micrograms/kg.hr PGE2 had no significant effect on the pancreatic juice volume and amylase secretion stimulated with 0.2 micrograms/kg.hr of cerulein. Intravenous injection of 100 micrograms/kg PGE2 inhibited both the volume and amylase secretion of pancreatic juice stimulated with 1 U/kg.h of secretin. The protective effect of PGE2 on cerulein-induced pancreatitis was not the stimulation on secretion but caused the cytoprotective effect of PG such as stabilization of cytoplasmic and lysosomal membrane.
为了阐明前列腺素E2（PGE2）对蛙皮素诱导的大鼠胰腺炎的影响，我们研究了PGE2与蛙皮素或促胰液素的相互作用。静脉输注10微克/千克·小时的蛙皮素，1小时后抑制胰腺外分泌，3小时后引起肉眼可见的水肿。给予PGE2可减轻超大剂量蛙皮素的抑制作用，并减轻胰腺水肿。100微克/千克·小时的PGE2对0.2微克/千克·小时蛙皮素刺激的胰液量和淀粉酶分泌无显著影响。静脉注射100微克/千克的PGE2可抑制1单位/千克·小时促胰液素刺激的胰液量和淀粉酶分泌。PGE2对蛙皮素诱导的胰腺炎的保护作用不是刺激分泌，而是产生了PG的细胞保护作用，如稳定细胞质膜和溶酶体膜。
