Finkelstein R, Nachum Z, Reissman P, Reiss N D, Besser M, Trajber I, Melamed Y
Department of Internal Medicine, Rambam Medical Center, Haifa, Israel.
Clin Infect Dis. 1992 Nov;15(5):771-3. doi: 10.1093/clind/15.5.771.
Bone involvement in patients with Gaucher's disease is common, and some of its clinical manifestations may resemble acute osteomyelitis. In addition, many studies have emphasized the high risk of secondary infection when surgical procedures are performed at the site of the involved bone. Nevertheless, these infections have never been well documented in the literature. Presentation of a patient with Gaucher's disease and osteomyelitis due to Prevotella (Bacteroides) melaninogenica provided us the opportunity to review 10 other similar case reports documented in the literature since 1966. This review suggests that acute hematogenic osteomyelitis is an uncommon complication of Gaucher's disease, but it is of interest that in most cases it is due to unusual organisms, particularly anaerobes.
戈谢病患者出现骨受累情况很常见，其一些临床表现可能类似急性骨髓炎。此外，许多研究强调在受累骨部位进行外科手术时继发感染的高风险。然而，这些感染在文献中从未得到充分记录。一名因产黑色素普雷沃菌（拟杆菌属）导致骨髓炎的戈谢病患者的病例，为我们提供了回顾自1966年以来文献中记载的其他10例类似病例报告的机会。该综述表明，急性血源性骨髓炎是戈谢病的一种罕见并发症，但有趣的是，在大多数情况下它是由不常见的微生物引起的，尤其是厌氧菌。
