Shirshev S V
Biull Eksp Biol Med. 1992 Jun;113(6):624-6.
The effect of chorionic gonadotropin (CG) on primary immune response was estimated according to the level of direct and indirect plaque-forming cells (PFC) on day 5, 8 and 12 after immunization of non-castrated and ovariectomized female mice of CBA strain. It was established, that on the 5th day CG (40-200 IU) did not influence the direct PFC level in ovariectomized animals, but stimulated them in non-ovariectomized mice (40 IU). In ovariectomized animals the selective immunodepressive effect of hormone on the IgG-PFC formation processes has been revealed. The CG effect depended on the time of PFC number examination as well as on the hormone dose. In non-castrated animals, where immunomodulating CG effects are partially mediated by ovarian hormones, the injection of hormone only in the dose of 200 IU significantly lowered the number of IgM and IgG-PFC. It is suggested, that sex steroids on the late stages of PFC formation, when the processes of isotype antibody synthesis switch take place, appear to be synergists of CG immunodepressive effect.
根据免疫后第5天、第8天和第12天CBA品系未阉割和去卵巢雌性小鼠中直接和间接空斑形成细胞（PFC）的水平，评估绒毛膜促性腺激素（CG）对初次免疫反应的影响。结果表明，在第5天，CG（40 - 200国际单位）对去卵巢动物的直接PFC水平没有影响，但在未去卵巢小鼠中（40国际单位）刺激了它们。在去卵巢动物中，已揭示激素对IgG - PFC形成过程具有选择性免疫抑制作用。CG的作用取决于PFC数量检查的时间以及激素剂量。在未阉割动物中，免疫调节性CG作用部分由卵巢激素介导，仅注射200国际单位剂量的激素会显著降低IgM和IgG - PFC的数量。有人提出，在PFC形成的后期阶段，当发生同种型抗体合成转换过程时，性类固醇似乎是CG免疫抑制作用的协同因子。
