Kevorkov N N, Shirshev S V, Kniazev Iu A
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):79-82.
A study was made of the effect of chorionic gonadotropin (CG) on the formation of a primary immune response and generation of antigen-specific T-suppressors in normal and ovariectomized female mice. CG at doses of 40 or 200 U. strongly suppressed the generation of suppressor cells in noncastrated animals, and significantly raised the level of a humoral immune response at a small dose (40 U.). In ovariectomized mice CG at various doses made a selective stimulating effect on T-suppressor generation which depended on the synthesis of endogenous prostaglandins. A CG effect resulted in a significant decrease in the level of a primary immune response in castrated animals. Choriogonin was assumed to cause an immunostimulating effect in normal female mice as a result of raised secretion of sex steroids by the ovaries. The hormone proper produced an immunosuppressive effect which was implemented at the level of suppressor cells.
研究了绒毛膜促性腺激素（CG）对正常和去卵巢雌性小鼠初次免疫反应形成及抗原特异性T抑制细胞产生的影响。40或200单位剂量的CG强烈抑制未阉割动物中抑制细胞的产生，且小剂量（40单位）时显著提高体液免疫反应水平。在去卵巢小鼠中，不同剂量的CG对T抑制细胞产生有选择性刺激作用，这取决于内源性前列腺素的合成。CG的作用导致去势动物初次免疫反应水平显著降低。推测绒毛膜促性腺激素由于卵巢性类固醇分泌增加而在正常雌性小鼠中产生免疫刺激作用。该激素本身产生免疫抑制作用，这在抑制细胞水平得以实现。
