Droogmans L, Cludts I, Cleuter Y, Kettmann R, Burny A
Laboratoire de Chimie Biologique, Université Libre de Bruxelles, Rhode-St-Genèse, Belgium.
DNA Seq. 1992;2(6):411-3. doi: 10.3109/10425179209020821.
We report the cloning of bovine interleukin-6 (IL-6) cDNA. The clone was isolated from a bovine-leukemia virus (BLV)-induced B cell-lymphosarcoma cDNA library cloned in the bacteriophage lambda gt11. The cDNA encodes a full length IL-6 protein made of 208 amino acids with 65, 53, 42 and 42% homology to published sequences of porcine, human, mouse and rat IL-6, respectively. The significance of IL-6 expression in a BLV-induced tumor is briefly discussed.
我们报道了牛白细胞介素-6（IL-6）cDNA的克隆。该克隆是从克隆于噬菌体λgt11的牛白血病病毒（BLV）诱导的B细胞淋巴瘤cDNA文库中分离得到的。该cDNA编码一个由208个氨基酸组成的全长IL-6蛋白，与已发表的猪、人、小鼠和大鼠IL-6序列的同源性分别为65%、53%、42%和42%。本文简要讨论了IL-6在BLV诱导的肿瘤中表达的意义。
