Timmenga E J, Das P K
Department of Surgical Research, University of Amsterdam, The Netherlands.
Br J Plast Surg. 1992 Oct;45(7):503-7. doi: 10.1016/0007-1226(92)90142-k.
In 11 New Zealand rabbits, small tissue expanders were placed in a pocket between the dermis and the panniculus carnosus and inflated during a period of 10 days. Animals were killed immediately after the inflation procedure (Group I, N = 4), 25 days thereafter (Group II, N = 5), and 35 and 55 days thereafter (Group III, N = 2). Dermal connective tissue architecture was studied by routine light microscopy. Specimens in group I showed a striking disturbance in polarity of the dermal collagen bundles. These changes were accompanied by a clear increase of cellular infiltration. In groups II and III, the collagen polarity showed a tendency to recover to normal, while cellular infiltration was decreased. The current findings indicate that there is a spontaneous repair of the damaged dermal collagen in expanded skin with time.
在11只新西兰兔中，将小型组织扩张器置于真皮和肌膜之间的袋囊中，并在10天内进行扩张。在扩张程序完成后立即处死动物（I组，n = 4），此后25天处死（II组，n = 5），以及此后35天和55天处死（III组，n = 2）。通过常规光学显微镜研究真皮结缔组织结构。I组标本显示真皮胶原束极性明显紊乱。这些变化伴随着细胞浸润明显增加。在II组和III组中，胶原极性有恢复正常的趋势，而细胞浸润减少。目前的研究结果表明，随着时间的推移，扩张皮肤中受损的真皮胶原会自发修复。
