Meigel W N, Gay S, Weber L
Arch Dermatol Res (1975). 1977 Jul 21;259(1):1-10. doi: 10.1007/BF00562732.
The human dermis consists of two morphologically different layers. A loose meshwork of thin collagenous fibres is characteristic for the adventitial dermis with includes the papillary and the periadnexal dermis. Thick, coarse collagen bundles are the main feature of the reticular dermis. Two different collagens, type I and type III occur in the dermis as shown previously by biochemical analyses. Antibodies specific for type I collagen or type III collagen and their corresponding precursors were used in indirect immunofluorescence tests to localize the various collagens in frozen sections of normal adult skin. Whereas type I collagen is found in all dermal layers, the main part of type III collagen can be found within the adventitial dermis. Antibodies against the precursor of type I collagen stain only a bandlike region immediately beneath the epidermis. Antibodies against the precursor of type III collagen stain the same regions as antibodies against the helical part of type III collagen.
人类真皮由两个形态不同的层组成。疏松的细胶原纤维网络是外膜真皮的特征，外膜真皮包括乳头层真皮和毛囊周围真皮。粗大的胶原束是网状真皮的主要特征。如先前生化分析所示，真皮中存在两种不同的胶原蛋白，即I型和III型。使用针对I型胶原蛋白或III型胶原蛋白及其相应前体的特异性抗体进行间接免疫荧光试验，以在正常成人皮肤的冰冻切片中定位各种胶原蛋白。虽然I型胶原蛋白存在于所有真皮层中，但III型胶原蛋白的主要部分可在外膜真皮中发现。针对I型胶原蛋白前体的抗体仅在表皮正下方的带状区域染色。针对III型胶原蛋白前体的抗体与针对III型胶原蛋白螺旋部分的抗体染色相同区域。
