Laasonen E M, Ehrström J, Toivakka E, Roukkula M
Rofo. 1977 Nov;127(5):483-6. doi: 10.1055/s-0029-1230746.
Side effects of metrizamide (Amipaque) and meglumine iocarmate (Dimer-X) were compared in lumbar myelography of 161 patients by a prospective, parallel, interview study. Severe complications were not observed. The percentage pairs of smaller complications were mainly in favour of Dimer-X, but in 2 of the 54 pairs only the difference did raise to a significant level. In one pair there were less symptomless patients after Amipaque-myelography (p less than 0.05) and in another pair the men had more headache after Amipaque-myelography (p less than 0.01). It may be possible to show with larger comparative series, that Amipaque has a tendency to cause more central-subcortical or meningeal-side effects than Dimer-X.
通过一项前瞻性、平行对照的访谈研究,对161例患者进行腰椎脊髓造影时,比较了甲泛葡胺(阿米培克)和碘卡明葡胺(二聚体-X)的副作用。未观察到严重并发症。较小并发症的百分比配对主要有利于二聚体-X,但在54对中的2对中,差异仅达到显著水平。在一对中,甲泛葡胺脊髓造影后无症状患者较少(p<0.05),在另一对中,甲泛葡胺脊髓造影后男性头痛较多(p<0.01)。通过更大规模的比较系列研究,有可能表明甲泛葡胺比二聚体-X更容易引起更多的中枢-皮质下或脑膜副作用。