MOORE K E, MILTON A S, GOSSELIN R E
Br J Pharmacol Chemother. 1961 Oct;17(2):278-85. doi: 10.1111/j.1476-5381.1961.tb01289.x.
5-Hydroxytryptamine, but not acetylcholine or catecholamines, stimulated the endogenous respiration of the excised gills of Modiolus demissus and mytilus edulis. Respiratory stimulation by 5-hydroxytryptophan is presumed to have occurred only after it had been decarboxylated to 5-hydroxytryptamine. 2-Bromolysergic acid diethylamide inhibited the effect of 5-hydroxytryptamine, while lysergic acid diethylamide mimicked it. The glycogen that was degraded during incubation of the gill cannot account for all of the oxygen that was consumed, indicating that some other substrate within the gill was also oxidized. That the metabolic actions of 5-hydroxytryptamine may be related to its cilio-acceleratory activity is discussed.
5-羟色胺能刺激偏顶蛤和紫贻贝离体鳃的内呼吸，而乙酰胆碱或儿茶酚胺则不能。5-羟色氨酸的呼吸刺激作用据推测仅在其脱羧形成5-羟色胺后才会发生。2-溴麦角酸二乙酰胺抑制了5-羟色胺的作用，而麦角酸二乙酰胺则模拟了它的作用。鳃在孵育过程中降解的糖原并不能解释所消耗的所有氧气，这表明鳃内的其他一些底物也被氧化了。文中讨论了5-羟色胺的代谢作用可能与其纤毛加速活性有关。
