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人类中受限抑制性T细胞活性的出现。

Occurrence of restricted suppressor T-cell activity in man.

作者信息

Bean M A, Kodera Y, Cummings K B, Bloom B R

出版信息

J Exp Med. 1977 Nov 1;146(5):1455-60. doi: 10.1084/jem.146.5.1455.

DOI:10.1084/jem.146.5.1455
PMID:144770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180973/
Abstract

Blood leukocytes from an immunologically hyporesponsive patient with urinary bladder carcinoma were found to be deficient in their ability to stimulate 3 of 27 responder leukocyte preparations from normal individuals in one-way mixed leukocyte culture (MLC). The patient's T-depleted leukocytes, however, functioned adequately as stimulator cells. T-enriched lymphocytes from this patient suppressed the MLC responsiveness of those three normals but not the responsiveness of other normals. The patient's cells suppressed the MLC responsiveness of only one of each of the parents of two of the normals who could be suppressed by the patient's leukocytes suggesting a possible genetic restriction to this suppressor cell activity.

摘要

在单向混合淋巴细胞培养（MLC）中，发现一名免疫反应低下的膀胱癌患者的血液白细胞刺激来自正常个体的27种反应性白细胞制剂中的3种的能力存在缺陷。然而，该患者的T细胞耗竭白细胞作为刺激细胞功能正常。来自该患者的富含T淋巴细胞抑制了这三名正常人的MLC反应性，但没有抑制其他正常人的反应性。该患者的细胞仅抑制了两名正常人中各自一名父母的MLC反应性，而这两名正常人的MLC反应性可被该患者的白细胞抑制，这表明这种抑制细胞活性可能存在遗传限制。

相似文献

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Occurrence of restricted suppressor T-cell activity in man.人类中受限抑制性T细胞活性的出现。
J Exp Med. 1977 Nov 1;146(5):1455-60. doi: 10.1084/jem.146.5.1455.
2
Decreased ability of blood leukocytes from patients with tumors of the urinary bladder to act as stimulator cells in mixed leukocyte culture.膀胱癌患者血液白细胞在混合白细胞培养中作为刺激细胞的能力下降。
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本文引用的文献

1
T cell control of antibody production.T细胞对抗体产生的控制。
Contemp Top Immunobiol. 1974;3:1-40. doi: 10.1007/978-1-4684-3045-5_1.
2
Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.人类T和B淋巴细胞的表面标志物。I. 大量与绵羊红细胞形成非免疫性玫瑰花结的淋巴细胞。
J Exp Med. 1972 Aug 1;136(2):207-15. doi: 10.1084/jem.136.2.207.
3
Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.细胞介导免疫反应中的调节机制。IV. 活化T淋巴细胞上混合淋巴细胞反应抑制因子受体的表达。
J Exp Med. 1976 Nov 2;144(5):1214-26. doi: 10.1084/jem.144.5.1214.
4
Suppressor T-cell abnormality in idiopathic systemic lupus erythematosus.特发性系统性红斑狼疮中抑制性T细胞异常。
Clin Immunol Immunopathol. 1976 Sep;6(2):192-9. doi: 10.1016/0090-1229(76)90110-0.
5
Aplastic anemia: presence in human bone marrow of cells that suppress myelopoiesis.再生障碍性贫血：人体骨髓中存在抑制骨髓生成的细胞。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2890-4. doi: 10.1073/pnas.73.8.2890.
6
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.小鼠抗体应答调节中抗原特异性抑制性T细胞因子的特性。IV. H-2组织相容性复合体内编码抑制性T细胞因子的基因的特殊亚区定位
J Exp Med. 1976 Sep 1;144(3):713-25. doi: 10.1084/jem.144.3.713.
7
Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.控制辅助性和抑制性T淋巴细胞上决定簇的H-2（I区）基因座的选择性表达。
J Exp Med. 1976 Sep 1;144(3):685-98. doi: 10.1084/jem.144.3.685.
8
Suppressor thymus-derived lymphocytes in fungal infection.真菌感染中胸腺来源的抑制性淋巴细胞
J Clin Invest. 1976 Feb;57(2):319-28. doi: 10.1172/JCI108283.
9
Altered lymphocyte functions in rats bearing syngeneic Moloney sarcoma tumors. II. Suppressor cells.同基因莫洛尼肉瘤肿瘤大鼠的淋巴细胞功能改变。II. 抑制细胞。
J Immunol. 1976 Aug;117(2):655-60.
10
Concanavalin A-activated suppressor cells in normal human peripheral blood lymphocytes.刀豆球蛋白A激活的正常人外周血淋巴细胞中的抑制细胞
Clin Exp Immunol. 1976 Oct;26(1):95-8.

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