PALMERIO C, MING S C, FRANK E, FINE J
J Exp Med. 1962 Mar 1;115(3):609-12. doi: 10.1084/jem.115.3.609.
Unilateral denervation of the renal pedicle was performed in a series of rabbits. 5 to 21 days later two intravenous injections of E. coli endotoxin were given 18 hours apart. In seven rabbits the generalized Shwartzman reaction developed in the non-denervated kidney. Four of the seven denervated kidneys did not show the reaction, and in the remaining three only a mild reaction was present. From these and previous observations we conclude that an intact sympathetic nervous system as well as endotoxin from the intestine, are necessary for the production of the generalized Shwartzman reaction.
对一系列兔子进行了肾蒂单侧去神经支配手术。5至21天后,相隔18小时进行两次大肠杆菌内毒素静脉注射。在7只兔子中,未去神经支配的肾脏发生了全身性施瓦茨曼反应。7只去神经支配的肾脏中有4只未出现该反应,其余3只仅出现轻微反应。根据这些以及之前的观察结果,我们得出结论,完整的交感神经系统以及来自肠道的内毒素,对于全身性施瓦茨曼反应的发生是必要的。