Tsantili-Kakoulidou A, Kier L B
Department of Pharmacy, University of Athens, Greece.
Pharm Res. 1992 Oct;9(10):1321-3. doi: 10.1023/a:1015865603263.
The odor strength of a series of alkylpyrazines has been quantitatively investigated applying molecular connectivity, molecular shape, and the recently developed electrotopological state indices. The successful use of the latter parameters indicates that both electronic and topological features contribute to the odor strength of the compounds under study, while the specific role of the two nitrogen atoms is revealed.
应用分子连接性、分子形状和最近开发的电子拓扑状态指数，对一系列烷基吡嗪的气味强度进行了定量研究。后一种参数的成功应用表明，电子和拓扑特征都对所研究化合物的气味强度有贡献，同时揭示了两个氮原子的具体作用。
