Bartolini L, Risaliti R, Pepeu G
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Pharmacol Biochem Behav. 1992 Dec;43(4):1161-4. doi: 10.1016/0091-3057(92)90497-4.
The effects of different doses of scopolamine, and of the nootropic drugs oxiracetam and aniracetam, were investigated on the performance of male Wistar rats in a T-maze requiring a spatial discrimination in the stem (reference memory) and an alternate discrimination in the arms (working memory). Criterion (90% correct responses) was reached within 3 days of daily training for stem and 9 days for arm discrimination. Scopolamine (0.1, 0.2, 0.6, and 1.0 mg/kg, SC, 60 min before session) significantly impaired working memory, as shown by a decrease in the number of correct alternations, without affecting reference memory. Both nootropic drugs (25-50 and 100 mg/kg PO) 30 min before scopolamine) attenuated the working memory impairment induced by scopolamine.
研究了不同剂量的东莨菪碱以及促智药奥拉西坦和阿尼西坦对雄性Wistar大鼠在T迷宫中表现的影响，该迷宫要求在茎部进行空间辨别（参考记忆）以及在臂部进行交替辨别（工作记忆）。在每天进行茎部辨别训练的3天内以及臂部辨别训练的9天内达到标准（正确反应率90%）。东莨菪碱（0.1、0.2、0.6和1.0mg/kg，皮下注射，训练前60分钟）显著损害工作记忆，表现为正确交替次数减少，但不影响参考记忆。两种促智药（25 - 50和100mg/kg，口服，在东莨菪碱前30分钟）减轻了东莨菪碱引起的工作记忆损害。
