Yavich L, Sirviö J, Heinonen E, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
J Neural Transm Park Dis Dement Sect. 1993;6(3):189-97. doi: 10.1007/BF02260921.
L-Deprenyl, a specific MAO-B inhibitor, has been reported to improve learning/memory in some cognitive tests in aged rats. The present study investigated whether L-deprenyl could alleviate the spatial learning deficit induced by muscarinic blockade and aging in OFA rats. Scopolamine (0.25 mg/kg) impaired the acquisition of a water maze task in adult rats and increased their swimming speeds. L-Deprenyl (0.25 mg/kg, 14 days) had no effect on water maze performance in saline treated adult rats, but markedly alleviated the learning deficit induced by scopolamine and increased the time and distance of swimming in the training quadrant when the platform was removed (spatial probe trial). L-Deprenyl partly reduced the effect of scopolamine on speed of swimming. Nevertheless, administration of l-deprenyl (0.25 mg/kg, 14 days) had no effect on spatial learning/memory in aged rats. We suggest that the l-deprenyl-scopolamine interaction in the water maze test may be considered as a premise for further investigations of l-deprenyl as cognition enhancer.
L-司来吉兰是一种特异性单胺氧化酶B抑制剂，据报道，在一些针对老年大鼠的认知测试中，它能改善学习/记忆能力。本研究调查了L-司来吉兰是否能缓解毒蕈碱阻断和衰老在OFA大鼠中诱导的空间学习缺陷。东莨菪碱（0.25毫克/千克）损害成年大鼠水迷宫任务的习得，并提高其游泳速度。L-司来吉兰（0.25毫克/千克，14天）对生理盐水处理的成年大鼠的水迷宫表现没有影响，但显著缓解了东莨菪碱诱导的学习缺陷，并在移除平台时（空间探索试验）增加了在训练象限的游泳时间和距离。L-司来吉兰部分降低了东莨菪碱对游泳速度的影响。然而，给予L-司来吉兰（0.25毫克/千克，14天）对老年大鼠的空间学习/记忆没有影响。我们认为，水迷宫试验中L-司来吉兰与东莨菪碱的相互作用可被视为进一步研究L-司来吉兰作为认知增强剂的前提。
