Jørgensen L J, Hansen A B, Burcharth F, Philipsen E, Horn T
Department of Pathology and Surgical Gastroenterology, Hvidovre Hospital, Denmark.
Ultrastruct Pathol. 1992 Nov-Dec;16(6):659-66. doi: 10.3109/01913129209023755.
In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, alpha 1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.
在两例胰腺实性假乳头状肿瘤（SPN）中，可见嗜银颗粒、嗜铬粒蛋白A、神经元特异性烯醇化酶、胰凝乳蛋白酶、α1抗胰蛋白酶、波形蛋白、细胞角蛋白和雌激素受体呈阳性染色。超微结构显示有神经分泌颗粒以及类酶原颗粒。平均核体积和体积校正有丝分裂指数的测量可区分SPN和胰腺高分化导管腺癌，SPN中的这些值明显较低。银染核仁组织区计数显示有广泛重叠。结果表明，SPN是一种具有内分泌和外分泌混合特征的肿瘤。与导管腺癌相比，其低恶性潜能体现在平均核体积和体积校正有丝分裂指数上。雌激素受体的存在可能在治疗上有用。
