Stömmer P, Kraus J, Stolte M, Giedl J
Institute of Pathology, University of Erlangen Nürnberg, West Germany.
Cancer. 1991 Mar 15;67(6):1635-41. doi: 10.1002/1097-0142(19910315)67:6<1635::aid-cncr2820670627>3.0.co;2-m.
Ten cases of the rare solid and cystic pancreatic tumors are presented. All except one occurred in young women (mean age, 25 +/- 9.2 years). The large neoplasms were evenly distributed across the pancreas; in one case, metastasis occurred; all other cases were free from disease after complete resection. Histologic hallmarks of solid and cystic neoplasms were papillary growth, large intracytoplasmic granules, and immunoreactivity with alpha 1-antitrypsin, alpha 1-antichymotrypsin, phospholipase A2, and neuroendocrine markers (neuron-specific enolase [NSE], synaptophysin). This suggests both endocrine as well as exocrine differentiation.
本文报告了10例罕见的实性和囊性胰腺肿瘤。除1例以外，其余均发生于年轻女性（平均年龄25±9.2岁）。大的肿瘤均匀分布于胰腺；1例发生转移；所有其他病例在完整切除后均无疾病。实性和囊性肿瘤的组织学特征为乳头状生长、大的胞质内颗粒以及与α1抗胰蛋白酶、α1抗糜蛋白酶、磷脂酶A2和神经内分泌标志物（神经元特异性烯醇化酶[NSE]、突触素）呈免疫反应性。这提示了内分泌以及外分泌分化。
