McCarter T L, Chen Y K
Department of Internal Medicine, Loma Linda University Medical Center, California.
Am J Gastroenterol. 1992 Dec;87(12):1855-8.
Isotretinoin, a retinoid derivative, is in wide use as a treatment for severe acne and other dermatologic conditions. Its effects on serum lipids, most notably the induction of hypertriglyceridemia, have been well documented. We present a case of a young woman with a previous history of gestational hyperlipidemia who developed hypertriglyceridemia and pancreatitis after initiation of isotretinoin therapy. A history of gestational hyperlipidemia may serve as a marker to help identify patients who are at increased risk for developing severe hypertriglyceridemia while receiving isotretinoin. Her case emphasizes the need to consider the possibility of pancreatitis in patients who develop abdominal pain while receiving this drug.
异维A酸，一种维甲酸衍生物，被广泛用于治疗重度痤疮和其他皮肤病。其对血脂的影响，尤其是诱导高甘油三酯血症，已有充分记录。我们报告一例年轻女性病例，该患者既往有妊娠高脂血症病史，在开始异维A酸治疗后发生了高甘油三酯血症和胰腺炎。妊娠高脂血症病史可能作为一个指标，有助于识别在接受异维A酸治疗时发生严重高甘油三酯血症风险增加的患者。她的病例强调了对于在接受该药治疗时出现腹痛的患者，需要考虑胰腺炎的可能性。
