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异维A酸引起的急性胰腺炎。

Acute Pancreatitis Caused by Isotretinoin.

作者信息

Ashraf Muddasir

机构信息

Hospital Medicine, UnityPoint Health Trinity Rock Island, Rock Island, USA.

出版信息

Cureus. 2020 Jun 20;12(6):e8710. doi: 10.7759/cureus.8710.

DOI:10.7759/cureus.8710
PMID:32699705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7372240/
Abstract

Isotretinoin, a retinoid derivative, is used widely as a treatment for severe acne and other dermatological conditions. Its effect on lipid metabolism, especially the induction of hypertriglyceridemia, is well documented. There are some case reports in the literature about drug-induced pancreatitis secondary to isotretinoin. We describe another interesting case of acute pancreatitis related to severe hypertriglyceridemia due to isotretinoin.

摘要

异维A酸是一种维甲酸衍生物，被广泛用于治疗重度痤疮和其他皮肤病。其对脂质代谢的影响，尤其是诱发高甘油三酯血症，已有充分记载。文献中有一些关于异维A酸继发药物性胰腺炎的病例报告。我们描述了另一例因异维A酸导致严重高甘油三酯血症相关的急性胰腺炎的有趣病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc48/7372240/a54ccf2a6bae/cureus-0012-00000008710-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc48/7372240/a54ccf2a6bae/cureus-0012-00000008710-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc48/7372240/a54ccf2a6bae/cureus-0012-00000008710-i01.jpg

相似文献

1
Acute Pancreatitis Caused by Isotretinoin.异维A酸引起的急性胰腺炎。
Cureus. 2020 Jun 20;12(6):e8710. doi: 10.7759/cureus.8710.
2
Marked hyperlipidemia and pancreatitis associated with isotretinoin therapy.与异维A酸治疗相关的显著高脂血症和胰腺炎。
Am J Gastroenterol. 1992 Dec;87(12):1855-8.
3
Acute pancreatitis secondary to isotretinoin-induced hyperlipidemia.异维A酸诱导的高脂血症继发急性胰腺炎
J Okla State Med Assoc. 2002 Feb;95(2):79-80.
4
An adolescent with abdominal pain taking isotretinoin for severe acne.一名患有严重痤疮正在服用异维A酸的腹痛青少年。
South Med J. 2006 Sep;99(9):992-4. doi: 10.1097/01.smj.0000223658.00852.d8.
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Facial edema induced by isotretinoin use: a case and a review of the side effects of isotretinoin.异维A酸引起的面部水肿：1例病例及异维A酸副作用综述
J Drugs Dermatol. 2006 May;5(5):467-8.
6
The use of gemfibrozil in a patient with chronic myelogenous leukemia to successfully manage retinoid-induced hypertriglyceridemia.在一名慢性粒细胞白血病患者中使用吉非贝齐成功治疗维甲酸诱导的高甘油三酯血症。
Clin Investig. 1993 Jan;71(1):74-7. doi: 10.1007/BF00210973.
7
Not every patient needs a triglyceride check, but all can get pancreatitis: a systematic review and clinical characterization of isotretinoin-associated pancreatitis.并非所有患者都需要检查甘油三酯，但所有患者都可能患胰腺炎：异维 A 酸相关胰腺炎的系统评价和临床特征。
Br J Dermatol. 2017 Oct;177(4):960-966. doi: 10.1111/bjd.15207. Epub 2017 Sep 19.
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Case Reports Hepatol. 2019 Jul 17;2019:9270827. doi: 10.1155/2019/9270827. eCollection 2019.
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Systemic treatment of severe acne with a retinoic acid derivative, isotretinoin.使用维甲酸衍生物异维A酸对重度痤疮进行全身治疗。
N Z Med J. 1984 Feb 22;97(750):115-7.
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High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study.异维A酸治疗痤疮期间出现高甘油三酯血症后发生高脂血症和代谢综合征的高风险：一项药物遗传学研究
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Isotretinoin-induced pancreatitis: is it time to definitely recognize it: a case report.异维A酸诱发的胰腺炎：是时候明确认识它了：一例病例报告
J Med Case Rep. 2025 Feb 21;19(1):66. doi: 10.1186/s13256-025-05097-2.
3
An Assessment of the Knowledge of Oral Isotretinoin (Roaccutane) Treatment Among Pharmacy Students in Saudi Arabia.

本文引用的文献

1
Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study.基于胰高血糖素样肽 1 的治疗与 2 型糖尿病患者急性胰腺炎住院风险的相关性：一项基于人群的匹配病例对照研究。
JAMA Intern Med. 2013 Apr 8;173(7):534-9. doi: 10.1001/jamainternmed.2013.2720.
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Association of oral glucocorticoid use with an increased risk of acute pancreatitis: a population-based nested case-control study.口服糖皮质激素使用与急性胰腺炎风险增加的关联：基于人群的巢式病例对照研究。
JAMA Intern Med. 2013 Mar 25;173(6):444-9. doi: 10.1001/jamainternmed.2013.2737.
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沙特阿拉伯药学专业学生对口服异维A酸（泰尔丝）治疗知识的评估
Cureus. 2023 Jun 13;15(6):e40388. doi: 10.7759/cureus.40388. eCollection 2023 Jun.
4
The Cost Utility of Nonpregnancy Laboratory Monitoring for Persons on Isotretinoin Acne Therapy.异维A酸治疗痤疮患者非妊娠实验室监测的成本效益
JID Innov. 2023 Jan 28;3(3):100186. doi: 10.1016/j.xjidi.2023.100186. eCollection 2023 May.
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Isotretinoin Induced Pancreatitis: A Rare Idiosyncratic Reaction.异维A酸诱发的胰腺炎：一种罕见的特异质性反应。
Indian J Dermatol. 2022 Nov-Dec;67(6):781-783. doi: 10.4103/ijd.ijd_206_22.
6
Hypertriglyceridemia may contribute to stroke and pancreatitis: A case report and review of the literature.高甘油三酯血症可导致卒中与胰腺炎：病例报告与文献复习。
Front Endocrinol (Lausanne). 2022 Dec 1;13:960343. doi: 10.3389/fendo.2022.960343. eCollection 2022.
Burden of gastrointestinal disease in the United States: 2012 update.
美国胃肠道疾病负担：2012 年更新。
Gastroenterology. 2012 Nov;143(5):1179-1187.e3. doi: 10.1053/j.gastro.2012.08.002. Epub 2012 Aug 8.
4
Acute pancreatitis and concomitant use of pancreatitis-associated drugs.急性胰腺炎和胰腺炎相关药物的同时使用。
Am J Gastroenterol. 2011 Dec;106(12):2183-8. doi: 10.1038/ajg.2011.303. Epub 2011 Sep 13.
5
Practice guidelines in acute pancreatitis.急性胰腺炎的实践指南。
Am J Gastroenterol. 2006 Oct;101(10):2379-400. doi: 10.1111/j.1572-0241.2006.00856.x.
6
An adolescent with abdominal pain taking isotretinoin for severe acne.一名患有严重痤疮正在服用异维A酸的腹痛青少年。
South Med J. 2006 Sep;99(9):992-4. doi: 10.1097/01.smj.0000223658.00852.d8.
7
Acute pancreatitis secondary to isotretinoin-induced hyperlipidemia.异维A酸诱导的高脂血症继发急性胰腺炎
J Okla State Med Assoc. 2002 Feb;95(2):79-80.
8
Review article: drug-induced pancreatitis.综述文章：药物性胰腺炎
Aliment Pharmacol Ther. 1996 Feb;10(1):23-38. doi: 10.1111/j.1365-2036.1996.tb00174.x.
9
Drug-induced pancreatitis.药物性胰腺炎
Drug Saf. 1996 Jun;14(6):406-23. doi: 10.2165/00002018-199614060-00006.
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Drug-associated pancreatitis: facts and fiction.药物相关性胰腺炎：事实与虚构
Pancreas. 1996 Jul;13(1):100-9. doi: 10.1097/00006676-199607000-00014.