McNamara R K, Kirkby R D, dePape G E, Corcoran M E
Department of Psychology, University of Victoria, BC, Canada.
Behav Brain Res. 1992 Sep 28;50(1-2):167-75. doi: 10.1016/s0166-4328(05)80298-0.
We investigated the effects of kindling and kindled seizures in different limbic structures on place and cue learning in the Morris water maze. The triggering of seizures by stimulation of the perforant path, septum, or amygdala prior to daily training impaired place learning, but had little effect on visible platform training or swim speed. Seizures triggered by stimulation of the medial perforant path after daily training also impaired place learning. Conversely, place learning proceeded normally in rats tested 24 h after kindling triggered by stimulation of the perforant path, septum, or amygdala, indicating that kindling per se does not affect place learning. Each group was able to learn the location of a reversed platform when pretraining seizures were discontinued; and perforant path and septal kindled rats, but not amygdaloid kindled rats, were impaired at learning the location of a reversed platform when seizures were triggered before training. The results confirm previous reports that limbic seizures produce amnesia, but they contradict the finding that hippocampal kindling impairs learning on tasks sensitive to hippocampal lesions.
我们研究了不同边缘结构的点燃及点燃性癫痫发作对Morris水迷宫中位置学习和线索学习的影响。在每日训练前通过刺激穿通通路、隔区或杏仁核引发癫痫发作会损害位置学习，但对可见平台训练或游泳速度影响不大。每日训练后通过刺激内侧穿通通路引发的癫痫发作也会损害位置学习。相反，在由刺激穿通通路、隔区或杏仁核引发点燃后24小时进行测试的大鼠中，位置学习正常进行，这表明点燃本身并不影响位置学习。当停止预训练癫痫发作时，每组大鼠都能够学会反转平台的位置；在训练前引发癫痫发作时，穿通通路和隔区点燃的大鼠，但杏仁核点燃的大鼠在学习反转平台位置时受到损害。结果证实了先前关于边缘性癫痫发作会导致失忆的报道，但与海马体点燃会损害对海马体损伤敏感任务的学习这一发现相矛盾。
