Leung L S, Brzozowski D, Shen B
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Behav Neurosci. 1996 Oct;110(5):1017-24. doi: 10.1037//0735-7044.110.5.1017.
The performance of rats that were partially kindled in the hippocampus was assessed on an 8-arm radial arm maze with 4 baited arms. In rats first trained and then kindled, deficits were found on a place task in which rats reached the goal arms of the maze using salient extramaze spatial cues, but not on an intramaze cue task in which rats reached the goal arms using salient intramaze cues. Acquisition of a new place task on the maze was not different between kindled and control rats. In conclusion, partial hippocampal kindling disrupted the retention but not the acquisition of a spatial or place task; retention of a nonspatial cue task was not disrupted.
在一个有4个诱饵臂的8臂放射状迷宫上评估海马体部分点燃的大鼠的表现。在首先接受训练然后被点燃的大鼠中，发现在一个位置任务中存在缺陷，即大鼠利用突出的迷宫外部空间线索到达迷宫的目标臂，但在一个迷宫内部线索任务中不存在缺陷，在该任务中大鼠利用突出的迷宫内部线索到达目标臂。点燃大鼠和对照大鼠在迷宫上获取新的位置任务方面没有差异。总之，海马体部分点燃破坏了空间或位置任务的记忆保持，但没有破坏其习得过程；非空间线索任务的记忆保持没有受到破坏。
