Zhou Xinghua
Center for Molecular Medicine L8:03 and Department of Medicine, Karolinska Hospital, Karolinska Institutet, 17176, Stockholm, Sweden.
Biomed Pharmacother. 2003 Sep;57(7):287-91. doi: 10.1016/s0753-3322(03)00082-9.
Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density lipoproteins from lesions suggest that a cell-mediated immune reaction is taking place in atherosclerosis. This review provides an overview of our current understanding of the roles of CD4(+) T cell subpopulations in atherosclerosis.
动脉粥样硬化是一种炎症性疾病。T淋巴细胞与巨噬细胞同时出现，在动脉粥样硬化病变中各个阶段都有大量存在。病变中的大多数T细胞是CD4(+) T细胞。病变中活化的T细胞和巨噬细胞的发现以及从病变中克隆出对修饰的低密度脂蛋白具有特异性的T细胞表明，动脉粥样硬化中正在发生细胞介导的免疫反应。本综述概述了我们目前对CD4(+) T细胞亚群在动脉粥样硬化中作用的理解。
