精神分裂症患者的亚甲基四氢叶酸还原酶基因多态性
Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia.
作者信息
Sazci Ali, Ergül Emel, Güzelhan Yalçin, Kaya Güner, Kara Ihsan
机构信息
Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41900 Derince, Kocaeli, Turkey.
出版信息
Brain Res Mol Brain Res. 2003 Sep 10;117(1):104-7. doi: 10.1016/s0169-328x(03)00327-9.
To investigate the role of methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 130 schizophrenic patients and 226 controls, using a polymerase chain reaction restriction fragment length polymorphism method. The MTHFR T677 allele was significantly distributed (chi(2)=7.900; P=0.019), between schizophrenic cases and healthy controls. The T677T genotype was overrepresented in the schizophrenic patients (OR=2.504; 95% CI=1.276-4.915; chi(2)=7.477; P=0.006). The T677T/A1298A, and C677T/C1298C compound genotypes were greater in the schizophrenic patients (OR=3.157; 95% CI=1.522-6.545; chi(2)=10.336; P=0.001 and OR=1.744; 95% CI=0.108-28.121; chi(2)=0.158; P=0.691, respectively). The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia.
为研究亚甲基四氢叶酸还原酶基因多态性在精神分裂症中的作用，我们采用聚合酶链反应-限制性片段长度多态性方法，分析了130例精神分裂症患者和226例对照者的MTHFR677和MTHFR1298基因型。MTHFR T677等位基因在精神分裂症患者和健康对照者之间分布存在显著差异（χ²=7.900；P=0.019）。T677T基因型在精神分裂症患者中过度表达（OR=2.504；95%CI=1.276-4.915；χ²=7.477；P=0.006）。T677T/A1298A和C677T/C1298C复合基因型在精神分裂症患者中更为常见（OR分别为3.157；95%CI=1.522-6.545；χ²=10.336；P=0.001和OR=1.744；95%CI=0.108-28.121；χ²=0.158；P=0.691）。MTHFR T677等位基因以及T677T和T677T/A1298A基因型是精神分裂症的遗传危险因素。
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