Hennig J, Pfister H, Ernst T, Ott D
Radiologische Klinik, Abt. Röntgendiagnostik, Freiburg, Germany.
NMR Biomed. 1992 Jul-Aug;5(4):193-9. doi: 10.1002/nbm.1940050406.
The absolute concentrations of the three major brain metabolites observable by in vivo proton spectroscopy--N-acetylaspartate(NAA), creatine and phosphocreatine (Cr and PCr) and choline (Cho)--have been measured at four standardized localizations in 34 healthy volunteers by in vivo localized proton spectroscopy using an external reference sample. The results show that the concentration of Cr and PCr as observed by in vivo MRS (5-6 mmol/L) is lower than that measured by other methods. The results are concordant with the hypothesis, that the Cr and PCr resonance as observed by proton spectroscopy is due mainly to PCr, whereas Cr remains invisible by being attached to a larger molecule. It is also demonstrated, that Cr and PCr is higher in the cerebellum than in the cerebrum, whereas NAA remains constant within the margin of error (8-9 mmol/L).
通过使用外部参考样本的体内局部质子波谱法，在34名健康志愿者的四个标准化定位点测量了体内质子波谱可观察到的三种主要脑代谢物——N-乙酰天门冬氨酸（NAA）、肌酸和磷酸肌酸（Cr和PCr）以及胆碱（Cho）的绝对浓度。结果表明，通过体内磁共振波谱法观察到的Cr和PCr浓度（5-6 mmol/L）低于其他方法测量的浓度。这些结果与以下假设一致，即质子波谱观察到的Cr和PCr共振主要归因于PCr，而Cr由于附着在更大的分子上而不可见。还证明，小脑的Cr和PCr高于大脑，而NAA在误差范围内保持恒定（8-9 mmol/L）。
