Doyle T J, Bedell B J, Narayana P A
Department of Radiology, University of Texas Medical School at Houston 77030, USA.
Magn Reson Med. 1995 Jun;33(6):755-9. doi: 10.1002/mrm.1910330603.
The relative distributions of N-acetylaspartate (NAA) + N-acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.
利用质子磁共振波谱成像（SI）测定了人脑灰质和白质中N-乙酰天门冬氨酸（NAA）+N-乙酰天门冬氨酰谷氨酸（NAAG）、肌酸+磷酸肌酸（Cr/PCr）和胆碱（Cho）的相对分布。SI数据使用自动波谱图像处理算法进行处理，并使用监督技术进行图像分割。线性回归分析表明，与白质相比，灰质中的NAA+NAAG（2.01 ppm）和Cr/PCr（3.02 ppm）峰更高。Cho（3.20 ppm）共振中观察到的受试者间较大差异妨碍了对其区域分布进行可靠评估。
