Pinder Matthew, Lummis Katie, Selinger Christian P
Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust.
Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust; University of Leeds, Leeds, UK.
Clin Exp Gastroenterol. 2016 Oct 14;9:325-335. doi: 10.2147/CEG.S96676. eCollection 2016.
Inflammatory bowel disease (IBD) affects many women of childbearing age. The course of IBD is closely related to pregnancy outcomes with poorly controlled IBD increasing the risk of prematurity, low weight for gestation, and fetal loss. As such, women with IBD face complex decision making weighing the risks of active disease versus those of medical treatments. This review summarizes the current evidence regarding the safety and efficacy of IBD treatments during pregnancy and lactation aiming to provide up-to-date guidance for clinicians. Over 50% of women have poor IBD- and pregnancy-related knowledge, which is associated with views contrary to medical evidence and voluntary childlessness. This review highlights the effects of poor patient knowledge and critically evaluates interventions for improving patient knowledge and outcomes.
炎症性肠病（IBD）影响着许多育龄女性。IBD的病程与妊娠结局密切相关，IBD控制不佳会增加早产、低出生体重和胎儿丢失的风险。因此，患有IBD的女性面临着复杂的决策，需要权衡疾病活动的风险与药物治疗的风险。本综述总结了目前关于IBD治疗在妊娠和哺乳期的安全性和有效性的证据，旨在为临床医生提供最新的指导。超过50%的女性对IBD和妊娠相关知识了解不足，这与违背医学证据的观点以及自愿不育有关。本综述强调了患者知识不足的影响，并批判性地评估了改善患者知识和结局的干预措施。
