Markey G M, Kettle P, Morris T C M, Connolly N, Foster H
Haematology Department, Belfast City Hospital, Belfast, BT9 7AB, UK.
Anal Cell Pathol. 2003;25(4):167-71. doi: 10.1155/2003/821978.
Direct measurement of monoclonal plasma cell mass in bone marrow biopsies may be a useful parameter to establish in plasma cell dyscrasia. In this study monoclonal plasma cells/mm in light chain immunoglobulin immunostained archival bone marrow sections from 22 patients in whom a diagnosis of multiple myeloma (MM) had been excluded but who had monoclonal proteins were counted by two observers at light microscopic level. There was good correlation between the counts of the two observers. The levels of monoclonal plasma cells/mm in biopsies were not related to the % counts in the aspirates taken at the same time as the biopsies. Three of seven patients with biopsy levels in excess of the polyclonal levels in patients without plasma cell dyscrasia developed progressive MM within the observation time. Monoclonal plasma cell levels/mm of bone marrow biopsies can be measured and they provide a useful parameter for the assessment of patients with low volume plasma cell dyscrasia.
在骨髓活检中直接测量单克隆浆细胞量可能是建立浆细胞异常增生症的一个有用参数。在本研究中，两名观察者在光学显微镜水平下对22例已排除多发性骨髓瘤（MM）诊断但有单克隆蛋白的患者的轻链免疫球蛋白免疫染色存档骨髓切片中的单克隆浆细胞/mm进行计数。两名观察者的计数之间有良好的相关性。活检中每毫米单克隆浆细胞水平与活检同时采集的抽吸物中的百分比计数无关。在观察期内，7例活检水平超过无浆细胞异常增生症患者多克隆水平的患者中有3例发展为进行性MM。骨髓活检中每毫米单克隆浆细胞水平可以测量，它们为评估低容量浆细胞异常增生症患者提供了一个有用的参数。
