Dornhoffer John L, Mamiya N, Bray P, Skinner Robert D, Garcia-Rill Edgar
Department of Otolaryngology/Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA.
J Vestib Res. 2002;12(5-6):205-9.
Sopite syndrome, characterized by loss of initiative, sensitivity to normally innocuous sensory stimuli, and impaired concentration amounting to a sensory gating deficit, is commonly associated with Space Motion Sickness (SMS). The amplitude of the P50 potential is a measure of level of arousal, and a paired-stimulus paradigm can be used to measure sensory gating. We used the rotary chair to elicit the sensory mismatch that occurs with SMS by overstimulating the vestibular apparatus. The effects of rotation on the manifestation of the P50 midlatency auditory evoked response were then assessed as a measure of arousal and distractibility. Results showed that rotation-induced motion sickness produced no change in the level of arousal but did produce a significant deficit in sensory gating, indicating that some of the attentional and cognitive deficits observed with SMS may be due to distractibility induced by decreased habituation to repetitive stimuli.
昏沉综合征的特征为主动性丧失、对通常无害的感觉刺激敏感以及注意力受损导致感觉门控缺陷，通常与太空晕动病（SMS）相关。P50电位的振幅是觉醒水平的一种度量，并且可以使用配对刺激范式来测量感觉门控。我们使用转椅通过过度刺激前庭器官来引发与太空晕动病相关的感觉不匹配。然后评估旋转对P50中潜伏期听觉诱发电位表现的影响，以此作为觉醒和注意力分散的一种度量。结果表明，旋转诱发的晕动病并未使觉醒水平发生变化，但确实导致了感觉门控方面的显著缺陷，这表明在太空晕动病中观察到的一些注意力和认知缺陷可能是由于对重复刺激的习惯化降低所诱发的注意力分散所致。
