Rütten Arno, Huschka Ulrich, Requena Celia, Rodríguez-Peralto José Luis, Requena Luis
Dermatopathologisches Gemeinschaftpraxis, Friedrichshafen, Germany.
Am J Dermatopathol. 2003 Oct;25(5):418-22. doi: 10.1097/00000372-200310000-00007.
Signet-ring cell malignant melanoma is a rare histopathologic variant of malignant melanoma with only a few described cases. We report the clinical, histopathological, and immunohistochemical features of two cases of primary cutaneous signet-ring cell malignant melanoma. Neoplastic melanocytes showed abundant clear cytoplasm compressing the nuclei to the periphery, sometimes resulting in a signet-ring appearance. Immunohistochemically, neoplastic melanocytes in both cases expressed immunoreactivity for the usual melanocytic markers S-100 protein and Melan-A, although only the second case resulted HMB-45 positive. We review the literature about this rare cytologic variant of malignant melanoma and discuss the differential diagnosis with other cutaneous neoplasms that may show a signet-ring cell appearance of their neoplastic cells.
印戒细胞恶性黑色素瘤是恶性黑色素瘤一种罕见的组织病理学变体，仅有少数病例报道。我们报告两例原发性皮肤印戒细胞恶性黑色素瘤的临床、组织病理学及免疫组化特征。肿瘤性黑素细胞显示丰富的透明细胞质，将细胞核挤压至周边，有时形成印戒样外观。免疫组化方面，两例肿瘤性黑素细胞均对常见黑素细胞标志物S-100蛋白和Melan-A呈免疫反应性，尽管仅第二例HMB-45呈阳性。我们回顾了关于这种罕见的恶性黑色素瘤细胞学变体的文献，并讨论了与其他可能显示肿瘤细胞印戒样外观的皮肤肿瘤的鉴别诊断。
