Sommers Karen R, Kong Kevin M, Bui Dang T, Fruehauf John P, Holcombe Randall F
Division of Hematology/Oncology, University of California and Chao Family Comprehensive Cancer Center, Irvine, CA, USA.
Anticancer Drugs. 2003 Sep;14(8):659-62. doi: 10.1097/00001813-200309000-00012.
A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.
一名接受每日放疗和低剂量（100 mg/m²）每日吉西他滨治疗的IV期恶性黑色素瘤患者出现了水疱性皮肤疹、发热和中性粒细胞减少，符合重叠型史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）。通过对受累区域进行皮肤活检确诊。描述了病例病史，并回顾了与化疗和放疗联合应用导致SJS/TEN发生相关的文献。本报告描述了吉西他滨与放疗同时使用的一种严重潜在并发症。
