1986 - 1998年意大利艾滋病患者确诊艾滋病后出现艾滋病定义性癌症的发病率。

Incidence of AIDS-defining cancers after AIDS diagnosis among people with AIDS in Italy, 1986-1998.

作者信息

Franceschi Silvia, Dal Maso Luigino, Pezzotti Patrizio, Polesel Jerry, Braga Claudia, Piselli Pierluca, Serraino Diego, Tagliabue Giovanna, Federico Massimo, Ferretti Stefano, De Lisi Vincenzo, La Rosa Francesco, Conti Ettore, Budroni Mario, Vicario Gianni, Piffer Silvano, Pannelli Franco, Giacomin Adriano, Bellù Francesco, Tumino Rosario, Fusco Mario, Rezza Giovanni

机构信息

Agency for Research on Cancer, Lyon, France.

出版信息

J Acquir Immune Defic Syndr. 2003 Sep 1;34(1):84-90. doi: 10.1097/00126334-200309010-00013.

DOI:10.1097/00126334-200309010-00013

PMID:14501799

Abstract

A record linkage was carried out between the Italian National Registry of AIDS and 19 cancer registries. The aim was to evaluate the 1986 through 1998 trends in incidence rate (IR) of AIDS-defining cancers (ADCs) among persons with AIDS (PWA) in Italy overall and according to various characteristics. A steady decrease in IRs was found for Kaposi sarcoma (KS) in men between 1986-1992 (2.5 per 100 person-years [py]) and 1997-1998 (1.0 per 100 py). Conversely, the first decrease in IRs of KS in women (from 0.9 to 0.6 per 100 py) and of non-Hodgkin lymphoma in both genders (from 1.7 to 0.7 per 100 py) was seen between 1993-1996 and 1997-1998, thus pointing to a favorable impact of highly active antiretroviral therapies. The decline was consistent across different age and HIV transmission groups, but it was more marked in PWA with a CD4 count >50 cells/microL than in PWA with more severe immune suppression. As a proportion of AIDS cases, invasive cervical cancer increased from 1.5% in 1993-1996 to 2.4% in 1997-1998, but IRs after AIDS could not be evaluated. On account of the marked decline of KS in men in 1997-1998, the overall burden of ADCs in Italy became similar in both genders.

摘要

在意大利国家艾滋病登记处与19个癌症登记处之间进行了一项记录链接。目的是评估1986年至1998年期间意大利艾滋病患者（PWA）中艾滋病定义癌症（ADC）发病率（IR）的总体趋势以及按各种特征划分的趋势。发现1986 - 1992年期间男性卡波西肉瘤（KS）的发病率（每100人年[py]为2.5例）与1997 - 1998年期间（每100 py为1.0例）呈稳步下降。相反，1993 - 1996年与1997 - 1998年期间，女性KS发病率首次下降（从每100 py的0.9例降至0.6例），男女非霍奇金淋巴瘤发病率均下降（从每100 py的1.7例降至0.7例），这表明高效抗逆转录病毒疗法产生了有利影响。不同年龄和HIV传播组的下降趋势一致，但CD4细胞计数>50个/微升的艾滋病患者下降更为明显，相比免疫抑制更严重的艾滋病患者。作为艾滋病病例的一部分，浸润性宫颈癌从1993 - 1996年的1.5%增至1997 - 1998年的2.4%，但艾滋病后的发病率无法评估。由于1997 - 1998年男性KS发病率显著下降，意大利ADC的总体负担在男女中变得相似。