Leiva J, Gaete P, Palestini M
Programa de Patología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Campus Oriente, Universidad de Chile, Casilla 16038, Santiago 9, Chile.
Arch Ital Biol. 2003 Oct;141(4):149-55.
The role of copper on the CA1 piramidal neurons and their sinaptic connections to the Schaffer's collateral was investigated using the field excitatory post-sinaptic potential (fEPSP). The same fEPSP was used to study copper effects on Long-term potentiation (LTP). We have found that copper 10 microM has an inhibitory action on the fEPSP. Similar effects were demonstrated with 10 microM of GABA. Moreover, copper showed a strong inhibitory action on the consolidated LTP. However, copper washout left a significant and persistent excitatory response. In our opinion, copper shows a dual sinaptic effect depending on the sinaptic experience.
使用场兴奋性突触后电位（fEPSP）研究了铜对CA1锥体神经元及其与沙弗氏侧支突触连接的作用。同样的fEPSP被用于研究铜对长时程增强（LTP）的影响。我们发现10微摩尔的铜对fEPSP有抑制作用。10微摩尔的GABA也表现出类似的效果。此外，铜对巩固的LTP有强烈的抑制作用。然而，洗去铜后留下了显著且持续的兴奋反应。我们认为，铜根据突触经历表现出双重突触效应。
