Vaquero J, Arias A, Zurita M, Coca S, Oya S, Morales C
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Oncol Res. 1992;4(7):275-80.
Using the experimental model of brain tumors induced by ethyl-nitrosourea (ENU), human recombinant interleukin-2 (rIL-2) and tumor necrosis factor-alpha (TNF-alpha) were administered to Wistar rats in early stages of carcinogenesis. The results obtained suggest that IL-2 does not influence the development of nervous system tumors. In contrast, TNF-alpha was capable of modulating the development of ENU-induced tumors, producing a reduction in the number of schwannomas and a delay in the appearance of intraparenchymatous brain tumors.
利用乙基亚硝基脲（ENU）诱导脑肿瘤的实验模型，在致癌作用早期将人重组白细胞介素-2（rIL-2）和肿瘤坏死因子-α（TNF-α）给予Wistar大鼠。获得的结果表明，IL-2不影响神经系统肿瘤的发生。相反，TNF-α能够调节ENU诱导肿瘤的发生，使施万细胞瘤数量减少，并延迟脑实质内肿瘤的出现。
